Can a Rare Brain Change What We Know About Early-Onset Alzheimer’s?
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Aliria Rosa Piedrahita de Villegas carried a rare genetic mutation making it extremely likely that she would develop Alzheimer’s disease in her 40s, like most others in her family with this genetic mutation. Something unexpected happened with Aliria though--she defied the odds and did not develop Alzheimer’s until she was 72. Six years after her diagnosis, Aliria’s Alzheimer’s hadn’t advanced much, but sadly,
she died of cancer. Scientists are now pondering whether her situation changes what they know about the genes that cause genetic early-onset Alzheimer’s.
Thirty Years of Research Studies Involved Aliria and her Family
For thirty years, Aliria and her family members had been followed by researchers from the University of Antioquia in Medellín in hopes of unlocking the secrets of early-onset Alzheimer’s disease. In that time, they encountered several people whose disease developed later than expected, in their 50s or even 60s. But none were as medically remarkable as Aliria.
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